Primary Immunodeficiency Diseases: A Molecular and Genetic Approach

Primary Immunodeficiency Diseases: A Molecular and Genetic Approach

E D I T E D B Y
Hans D. Ochs , MD
C. I. Edvard Smith , MD, PhD
Jennifer M. Puck , MD

The first edition of this masterfully written and edited compendium on the subject of primary immunodeficiency diseases contained descriptions of about 70 entities. The second edition, published 8 years later, described about 120 distinct primary immunodeficiency diseases.

 

Primary Immunodeficiency Diseases: A Molecular and Genetic Approach

The current third edition, in 2013, details about 250 conditions. This exponential increase in the recognition of errors in host defense has occurred in diminishing intervals of time, attesting to the rapid advances in genetics, molecular biology, and cell biology and the equally fast application of basic science in clinical medicine.

In examining the recent literature, we have found descriptions of five new immunodeficiencies in one week, so the field continues to grow. Similarly, these advances have begun to move into translational medicine with more frequent, but still early, reports of successful therapies.

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