MicroRNAs in malignant tumors of the skin PDF Download

MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine 1st ed. 2016 Edition PDF Download
by PD Dr. Michael Sand (Author)

Michael Sand gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin. This book is a postdoctoral thesis on miRNAs in cutaneous malignant melanoma and non-melanoma skin cancer with a focus on the miRNA processing machinery and miRNA expression profiling. The research presented in this book was performed in the Dermatologic Surgery Section at the Department of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin.

In  malignant  tumors,  uncontrolled  cell  replication  occurs,  which  can  be caused by a loss of function of tumor suppressor genes or the activation of  oncogenes.  These  alterations  have  an  immediate  effect  on  thecell cycle.  As  a  component  of  tumorigenesis,  uncontrolled  cell  division manifests  clinically  as  a  malignant  tumor.  A  number  of  studies have shown  that  the  regulation  of  both  tumor  suppressor  genes  and  tumor growth-promoting oncogenes is regulated by microRNAs (miRNAs) [1-3]. Whether miRNAs  in  skin  tumors  also  assume  a molecular-pathological role has not been investigated to any great extent and is the subject of this work. 

MicroRNAs in malignant tumors of the skin PDF Download

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