Increasing the Therapeutic Ratio of Radiotherapy 2016 PDF

Increasing the Therapeutic Ratio of Radiotherapy (Cancer Drug Discovery and Development) PDF
by Philip J. Tofilon (Author, Editor), Kevin Camphausen (Author, Editor)

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy.

In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.

Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).

Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

  Improving  the  Therapeutic  Ratio  of  Radiotherapy 
by Targeting the DNA Damage Response ………………………………………  1 
Ross  Carruthers  and  Anthony  J.  Chalmers 
 2  Receptor  Tyrosine  Kinases  as  Targets  for  Enhancing  Tumor 
Radiosensitivity ……………………………………………………………………………  35 
Thomas  J.  Hayman  and  Joseph  N.  Contessa 
 3  Histone  Deacetylase  Inhibitors  and  Tumor  Radiosensitization ……….  57 
Elizabeth  I.  Spehalski ,  Philip  J.  Tofi lon ,  and  Kevin  Camphausen 
 4  Radioprotection  as  a  Method  to  Enhance  the  Therapeutic 
Ratio of Radiotherapy ………………………………………………………………….  79 
Su  I.  Chung ,  DeeDee  K.  Smart ,  Eun  Joo  Chung ,  and  Deborah  E.  Citrin 
 5  Application  of  Functional  Molecular  Imaging 
in Radiation Oncology ………………………………………………………………….  103 
Sarwat  Naz ,  Murali  C.  Krishna ,  and  James  B.  Mitchell 
 6  Remodeling  the  Irradiated  Tumor  Microenvironment: 
The Fifth R of Radiobiology?………………………………………………………..  135 
Mary  Helen  Barcellos-Hoff 
 7  Combining  Radiotherapy  and  Immunotherapy: 
Emerging Preclinical Observations of Lymphocyte 
Costimulatory and Inhibitory Receptor Modulation ……………………..  151 
Robert  M.  Samstein ,  Sadna  Budhu ,  Taha  Mergoub , 
and  Christopher  A.  Barker 
 8  Stereotactic  Body  Radiation  Therapy  (SBRT)  or  Alternative 
Fractionation Schedules ……………………………………………………………….  171 
Aaron  M.  Laine ,  Zabi  Wardak ,  Michael  R.  Folkert , 
and  Robert  D.  Timmerman 
Contents 
vi
 9  Novel  Imaging  for  Treatment  Planning  or  Tumor  Response …………..  203 
Adam  Gladwish  and  Kathy  Han 
10  Increasing  the  Therapeutic  Efficacy  of  Radiotherapy  Using 
Nanoparticles……………………………………………………………………………….  241 
Ajlan  Al  Zaki ,  David  Cormode ,  Andrew  Tsourkas ,  and  Jay  F.  Dorsey 
Index…………………………………………………………………………………………………..  267

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