Free Lipospheres in Drug Targets and Delivery pdf download

Free Lipospheres in Drug Targets and Delivery pdf download – medical books free download

Colloidal drug carriers, such as liposomes and lipid nanoparticles, are able to modify the in vivo distribution of associated substances. They, therefore, can be used to improve the therapeutic index of drugs by increasing their efficacy or reducing their toxicity. If these delivery systems are carefully designed with respect to the target and route of administration, they help us to overcome some of the delivery problems posed by new classes of active molecules, such as peptides, proteins, genes, and oligonucleotides. They may also extend the therapeutic potential of established drugs, such as doxorubicin and amphotericin B. This book describes the use of lipid-based nano- and microparticulate carriers in such applications. It presents innovative methods of delivering active biochemicals to different systems, discusses lipospheres as a technical solution to problems associated with controlled release of biochemicals, covers lipospheres as carriers for vaccines, and finally provides procedures for specific applications and describes biological systems. With the identification, characterization, and cloning of specific growth factors, recombinant proteins are now widely used in the clinic. The use of recombinant hematopoietic growth factors has, for example, allowed the clinical manipulation of the hematopoietic system. Recombinant human granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor are now widely used to mobilize hematopoietic stem cells, thereby providing a source of hematopoietic stem cells for autologous or allogeneic transplantation. However, one disadvantage associated with the use of most recombinant molecules is their rapid clearance. Because of this rapid clearance, recombinant molecules require repeated administration to achieve biological efficacy. Initially, continuous infusion was used to address this pharmacological deficiency. Continuous infusion has the advantage of delivering drugs in a controlled manner and is particularly appropriate when it is important to maintain constant plasma drug concentrations. However, the requirement for continuous venous access and the use of ambulatory pumps limits its use. In this context, other approaches have been developed to improve the pharmacokinetic and pharmacodynamic properties of recombinant proteins in vivo. These have included the addition of polyethylene glycol to the recombinant molecules (PEGylation) and the use of sustained-release delivery systems. One goal of these approaches is to achieve clinical efficacy and lower the number of administrations, possibly to single injections, and thereby increase patient compliance. In addition to improving the pharmacokinetic and pharmacodynamic profile of recombinant molecules, sustained release may also increase the biological activity of specific molecules. Moreover, it should be acknowledged that the use of an efficient carrier for nucleic acid–based medicines is considered to be a determinant factor for the successful 1692_C00.fm Page v Monday, October 25, 2004 9:00 AM © 2005 by CRC Press LLC application of gene therapy. However, the drawbacks associated with the use of viral vectors, namely, those related to safety problems, have prompted investigators to develop alternative methods for gene delivery, with cationic lipid-based systems being the most representative systems. Despite extensive research in the last decade on the use of cationic liposomes as gene transfer vectors, and the development of elegant strategies to enhance their biological activity, these systems are still far from being viable alternatives to the use of viral vectors in gene therapy. Finally, in this book considerations are made regarding the structure–activity relationships of cationic liposphere/DNA complexes, and the key formulations are presented and discussed in terms of their effect on biological activity.

Lipospheres in Drug Targets and Delivery

Lipospheres in Drug Targets and Delivery

Table of Contents Lipospheres in Drug Targets and Delivery pdf download

Chapter 1:  Solid Lipid Nanoparticles — Concepts, Procedures, and Physicochemical Aspects………………………………………………………………………………………………………..1

Karsten Mäder and Wolfgang Mehnert

Chapter 2:  Production of Lipospheres for Bioactive Compound Delivery …………………………23

Elisabetta Esposito, Rita Cortesi, and Claudio Nastruzzi

Chapter 3:  Characterization of Solid Lipid Nano- and Microparticles ………………………………41

Heike Bunjes

Chapter 4:  Lipospheres as Delivery Systems for Peptides and Proteins…………………………….67

Stephanie Könnings and Achim Göpferich

Chapter 5:  Lipospheres for Vaccine Delivery …………………………………………………………………87

Abraham J. Domb, Aviva Ezra, and Boaz Mizrahi

Chapter 6: Solid Lipid Nanoparticles: Interaction with Cells, Cytokine Production, and Enzymatic Degradation

Carsten Olbrich, Kerstin Tabatt, Sylvia A. Wissing, Nadja Schöler, and R.H. Müller

Chapter 7: Delivery of Lipophilic Compounds with Lipid Nanoparticles — Applications in Dermatics and for Transdermal Therapy

Monika Schäfer-Korting and Wolfgang Mehnert

Chapter 8 Cationic Lipospheres as Delivery Systems for Nucleic Acid Molecules………….143 Rita Cortesi, Elisabetta Esposito, and Claudio Nastruzzi

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