Download Prognostic and Predictive Factors in Gynecologic Cancers PDF

Download Prognostic and Predictive Factors in Gynecologic Cancers PDF
by Charles F. Levenback (Editor), Anil Sood (Editor), Karen H Lu (Editor), Robert Coleman (Editor)

Gynecologic oncology takes a fresh look at a critical aspect of cancer treatment planning. An international team of authors reviews the traditional prognostic and predictive factors such as tumor grade, histologic subtype, and grade and then goes a step further to review the growing number of molecular discoveries that have increasing clinical significance. The book is organized into comprehensive sections on ovarian, endometrial and cervical cancer and includes up to date reviews, newly discovered molecular pathways, genetic markers, molecular imaging techniques, and their relevance to clinical medicine.

Prognostic and Predictive Factors in Gynecologic Oncology is illustrated with over 100 figures and is essential reading for oncologists, translational and basic scientists, as well as fellows, residents and students with a special interest in gynecologic oncology.

Experienced clinicians have long recognized limitations with regard to predicting the course of disease in individual patients.We rely heavily on the traditional prognostic and predictive factors such as tumor stage, histologic subtype and grade to provide broad guidelines for treatment recommendations.At the extremes of the prognostic spectrum, for example stage I and IV cervix cancer, traditional prognostic factors are fairly reliable. Nevertheless, we also know that occasionally patients with a favorable prognosis will suffer from recurrent cancer and conversely,
patients with a terrible prognosis survive. In more ambiguous categories (for example stage II and III epithelial ovarian cancer), prognostication for individual patients can be particularly difficult. This high degree of uncertainty contributes to the patient’s (and provider’s) anxiety and leads to over-treatment of large numbers of patients. There is a growing number of new prognostic and predictive factors that have been derived from molecular discoveries.These newly described molecular pathways and genetic markers are starting to become the basis of therapeutic intervention. We anticipate that in the coming years, treatment planning will be based on molecular profiling to a greater extent. Eventually, the traditional prognostic factors that we rely on so heavily now may be either complemented or superceded by molecular factors. Our purpose in writing this book is to provide a single up-to-date resource of prognostic and predictive factors from both traditional and molecular categories for gynecologic malignancies.We hope that this book will be an easy to use resource for oncologists, translational and basic researchers, as well as fellows, residents and students who have an interest in gynecologic cancers. In order to provide a concise resource, we elected to focus on specific aspects of the major gynecologic cancers including ovarian, endometrial, and cervical cancer. Our hope is that this book will not only help clinicians at the bedside make informed treatment recommendations, but also stimulate scientists to continue to search for better prognostic and predictive markers for our patients

List of Contributors ix
Preface xv
Section I: Ovary(Section Editor:Anil K Sood)
1. Clinical predictors of outcome in epithelial ovarian carcinoma 1
Teresa P Díaz-Montes and Robert E Bristow
2. Influence of BRCA1and BRCA2on ovarian cancer survival 15
Christina S Chu and Stephen C Rubin
3. Cell cycle and apoptotic markers 27
John H Farley
4. TP53/p53 as a prognostic factor 45
Stephen L Rose
5. Molecular profiling in ovarian cancer 63
Michael J Birrer, Kristin K Zorn, and Ginger J Gardner
6. Angiogenesis and epithelial ovarian carcinoma 83
Yvonne G Lin, Robert B Jaffe, and Anil K Sood
7. Cell adhesion and matrix-associated proteins in ovarian carcinoma 101
Ben Davidson, Claes G Tropé, and Reuven Reich
8. Immune biomarkers in ovarian cancer 125
George Coukos, Ioannis Alagkiozidis, Sarah Kim, Mark Cadungog, Sarah Adams,
Christina Chu, José Ramon Conejo-Garcia,Weiping Zou,Tyler Curiel,
Dionysios Katsaros, Lin Zhang, and Phyllis Gimotty
9. Predictive factors in germ cell and stromal tumors 141
Jubilee Brown
Section II:Endometrium(Section Editor: Karen H Lu)
10. Rethinking traditional surgical–pathologic criteria for early  153
endometrial cancer: studies of patterns of failure
Andrea Mariani, Sean C Dowdy, and Karl C Podratz
11. Molecular prognostic and predictive factors in advanced endometrial  171
cancer: implications for therapy
Grainger S Lanneau and D Scott McMeekin
12. Endometrial cancer associated with defective DNA mismatch repair 185
Karen H Lu and Russell R Broaddus
13. Molecular profiling in endometrial cancer: current research and  197
implications for the future
Michael A Bidus, John I Risinger, and G Larry Maxwell
14. Prognostic markers of uterine papillary serous carcinoma 217
Brian M Slomovitz and Warner K Huh
15. Predictors of outcome in malignant mixed müllerian tumors of the uterus 225
Elizabeth D Euscher, Robin A Lacour, and Lois M Ramondetta
Section III: Cervical(Section Editor: Robert L Coleman)
16. Clinical–pathologic predictors in patients with cervical cancer 233
Davansu Tewari and Bradley J Monk
17. Predictors of radiation sensitivity and resistance 259
Anuja Jhingran
18. Molecular prognostic and predictive factors in cervical cancer 269
Jayanthi S Lea and Carolyn Y Muller
19. Virology in the prevention and management of cervical cancer 281
Jason D Wright
20. Molecular imaging of cervical cancer 293
Matthew A Powell and Perry W Grigsby
21. Neuroendocrine cancer of the cervix: prognostic and predictive factors 307
John K Chan and Daniel S Kapp
22. Predictive values of sentinel lymph nodes 325
Michael Frumovitz, Robert L Coleman, and Charles F Levenbac

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