Download Harrison’s Hematology and Oncology, 3E (2016) PDF
Download Harrison's Hematology and Oncology, 3E (2016) PDF
by Dan Longo (Author)
Hematology and Oncology – backed by the unmatched authority of Harrison’s
Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.
• Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities
• Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas
• Integration of pathophysiology with clinical management
• High-yield board review questions make this text ideal for keeping current or preparing for the boards
• Valuable appendix of laboratory values of clinical importance
Harrison’s Principles o Internal Medicine has a long and distinguished tradition in the eld o hematology. Maxwell Wintrobe, whose work actually established hematology as a distinct subspecialty o medicine, was a ounding editor o the book and participated in the rst seven editions, taking over or insley Harrison as editor-in-chie on the sixth and seventh editions. Wintrobe, born in 1901, began his study o blood in earnest in 1927 as an assistant in medicine at ulane University in New Orleans. He continued his studies at Johns Hopkins rom 1930 to 1943 and moved to the University o Utah in 1943, where he remained until his death in 1986. He invented a variety o the measures that are routinely used to characterize red blood cell abnormalities, including the hematocrit, the red cell indices, and erythrocyte sedimentation rate, and de ned the normal and abnormal values or these parameters, among many other important contributions in a 50-year career.Oncology began as a subspecialty much later. It came to li e as a speci c subdivision within hematology. A subset o hematologists with a special interest in hematologic malignancies began working with chemotherapeutic agents to treat leukemia and lymphoma in the mid-1950s and early 1960s. As new agents were developed and the principles o clinical trial research were developed, the body o knowledge o oncology began to become larger and mainly independent rom hematology. In ormed by the laboratory study o cancer biology and an expansion in ocus beyond hematologic neoplasms to tumors o all organ systems, oncology developed as a separable discipline rom hematology.
Tis separation was also ueled by the expansion o the body o knowledge about clotting and its disorders, which became a larger part o hematology.In most academic medical centers, hematology and oncology remain connected. However, conceptual distinctions between hematology and oncology have been made. Di erences are rein orced by separate ellowship training programs (although many joint training programs remain), separate board certi cation examinations, separate pro essional organizations, and separate textbooks describing separate bodies o knowledge. In some academic medical centers, oncology is not merely a separate subspecialty division in a Department o
Medicine but is an entirely distinct department in the medical school with the same standing as the Department o Medicine. Economic orces are also at work to separate hematology and oncology.Perhaps I am only ref ecting the biases o an old dog, but I am unenthusiastic about the increasing ractionation o medicine subspecialties. T ere are now invasive and noninvasive cardiologists, gastroenterologists who do and others who do not use endoscopes, and organ- or individual disease- ocused subspecialists (diabetologists, thyroidologists) instead o organ system–ocused subspecialists (endocrinologists). T is ractionation has also begun within hematology and oncology. Some oncologists specialize in a singletype o cancer and divisions o hematology have designated experts in clotting. At a time when thebody o knowledge that must be mastered is increasing dramatically, the duration o training has not been increased to accommodate the additional learning that is necessary to become highly skilled. Extraordinary attention has been ocused on the hours that trainees work. Apparently, the administrators are more concerned about undocumented adverse e ects o every third night call on trainees than they are about the well-documented adverse e ects on patients o requent hando s o patient responsibility to multiple caregivers.
Despite the sub-sub-subspecialization that is pervasive in modern medicine, students, trainees, general internists, amily medicine physicians, physicians’ assistants, nurse practitioners, and specialists in nonmedicine specialties still require access to in ormation in hematology and oncology that can assist them in meeting the needs o their patients. Given the paucity o single sources o integrated in ormation on hematology and oncology, the editors o Harrison’s Principles o Internal Medicinedecided to pull together the chapters in the “mother book” related to hematology and oncology and bind them together in a subspecialty themed book called Harrison’s Hematology and Oncology. T e rst edition o this book appeared in 2010 and was based on the 17th edition
o Harrison’s Principles o Internal Medicine. A second edition based on 18th edition o Harrison’s Principles o Internal Medicine appeared in 2013. T is third edition is derived rom the 19th edition o Harrison’s Principles o Internal Medicine. T e book contains 57 chapters organized into 12 sections: (I) T e Cellular Basis o H ematop oiesis, ( I I ) Card in al Man i estation s o Hematologic Diseases, (III) Anemias, (IV) Myeloproli erative Disorders, (V) Hematologic Malignancies, (VI) Disorders o Hemostasis, (VII) Biology o Cancer, (VIII) Principles o Cancer Prevention and reatment, (IX) Neoplastic Disorders, (X) Endocrine Neoplasia, (XI) Remote E ects o Cancer, and (XII) Oncologic Emergencies and Late E ects and Complications o Cancer and Its reatment
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