Download Harrison’s Hematology and Oncology, 3E (2016) PDF

Download Harrison's Hematology and Oncology, 3E (2016) PDF
by Dan Longo (Author)

Hematology and Oncology – backed by the unmatched authority of Harrison’s

Featuring a superb compilation of chapters related to hematology and oncology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s.  You will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation.


• Each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities
• Chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas
• Integration of pathophysiology with clinical management
• High-yield board review questions make this text ideal for keeping current or preparing for the boards
• Valuable appendix of laboratory values of clinical importance

Harrison’s  Principles  o  Internal  Medicine has a long and distinguished tradition in the  eld o hematology. Maxwell  Wintrobe,  whose  work  actually  established hematology as a distinct subspecialty o medicine, was a  ounding  editor  o  the  book  and  participated  in  the rst seven editions, taking over or insley Harrison as  editor-in-chie  on  the  sixth  and  seventh  editions. Wintrobe,  born  in  1901,  began  his  study  o  blood  in earnest  in  1927  as  an  assistant  in  medicine  at   ulane University  in  New  Orleans.  He  continued  his  studies at Johns Hopkins rom 1930 to 1943 and moved to the University o Utah in 1943, where he remained until his death in 1986. He invented a variety o the measures that are routinely used to characterize red blood cell abnormalities, including the hematocrit, the red cell indices, and erythrocyte sedimentation rate, and de  ned the normal and abnormal values or these parameters, among many other important contributions in a 50-year career.Oncology  began  as  a  subspecialty  much  later.  It came  to  li e  as  a  speci  c  subdivision  within  hematology.  A  subset  o  hematologists  with  a  special  interest in hematologic malignancies began working with chemotherapeutic agents to treat leukemia and lymphoma in the mid-1950s and early 1960s. As new agents were developed  and  the  principles  o  clinical  trial  research were  developed,  the  body  o  knowledge  o  oncology began to become larger and mainly independent rom hematology. In ormed by the laboratory study o cancer biology and an expansion in ocus beyond hematologic neoplasms  to  tumors  o  all  organ  systems,  oncology developed  as  a  separable  discipline  rom  hematology. 
Tis separation was also ueled by the expansion o the body  o  knowledge  about  clotting  and  its  disorders, which became a larger part o hematology.In most academic medical centers, hematology and oncology remain connected. However, conceptual distinctions between hematology and oncology have been made. Di  erences are rein orced by separate ellowship training programs (although many joint training programs  remain),  separate  board  certi  cation examinations, separate pro essional organizations, and separate textbooks describing separate bodies o knowledge. In some academic medical centers, oncology is not merely a  separate  subspecialty  division  in  a  Department  o 
Medicine but is an entirely distinct department in the medical school with the same standing as the Department o Medicine. Economic orces are also at work to separate hematology and oncology.Perhaps I am only ref ecting the biases o an old dog, but I am unenthusiastic about the increasing ractionation o medicine subspecialties. T ere are now invasive and noninvasive cardiologists, gastroenterologists who do and others who do not use endoscopes, and organ- or individual  disease- ocused  subspecialists  (diabetologists, thyroidologists) instead o organ system–ocused subspecialists  (endocrinologists).  T is  ractionation has also begun within hematology and oncology. Some oncologists specialize in a singletype o cancer and divisions  o  hematology  have  designated  experts  in  clotting. At a time when thebody o knowledge that must be mastered is increasing dramatically, the duration o training has not been increased to accommodate the additional learning that is necessary to become highly skilled.  Extraordinary  attention  has  been  ocused  on the hours that trainees work. Apparently, the administrators  are  more  concerned  about  undocumented adverse e  ects o every third night call on trainees than they are about the well-documented adverse e  ects on patients o requent hando  s o patient responsibility to multiple caregivers.
Despite  the  sub-sub-subspecialization  that  is pervasive  in  modern  medicine,  students,  trainees, general  internists,  amily  medicine  physicians,  physicians’  assistants,  nurse  practitioners,  and specialists  in  nonmedicine  specialties  still  require  access  to in ormation  in  hematology  and  oncology  that  can assist  them  in  meeting  the  needs  o  their  patients. Given the paucity o single sources o integrated in ormation on hematology and oncology, the editors o Harrison’s Principles o Internal Medicinedecided to pull together the chapters in the “mother book” related to hematology and oncology and bind them together in a subspecialty themed book called Harrison’s Hematology  and  Oncology.  T e   rst  edition  o  this  book appeared in 2010 and was based on the 17th edition 
o Harrison’s Principles o Internal Medicine. A second edition based on 18th edition o Harrison’s Principles o Internal Medicine appeared in 2013. T is third edition  is  derived  rom  the  19th  edition  o  Harrison’s Principles o Internal Medicine. T e book contains 57 chapters  organized  into  12  sections:  (I)  T e  Cellular Basis  o  H ematop oiesis,  ( I I )  Card in al  Man i  estation s o Hematologic Diseases, (III) Anemias, (IV) Myeloproli erative  Disorders,  (V)  Hematologic Malignancies,  (VI)  Disorders  o  Hemostasis,  (VII)  Biology  o Cancer,  (VIII)  Principles  o  Cancer  Prevention  and reatment, (IX) Neoplastic Disorders, (X) Endocrine Neoplasia, (XI) Remote E  ects o Cancer, and (XII) Oncologic Emergencies and Late E  ects and Complications o Cancer and Its  reatment

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