Download Connective Tissue Disease: A Comprehensive Guide 2016 PDF

Download Connective Tissue Disease: A Comprehensive Guide 2016 PDF
by Dario Roccatello (Editor), Lorenzo Emmi (Editor)

In this volume devoted to systemic lupus erythematosus (SLE) and Sjögren syndrome, leading specialists from different disciplines present the latest research findings on many aspects of the diseases and describe the most recent trends in treatment, such as the “treat to target” approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, encompassing, for example, epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, relationships with other disorders, biological therapy of SLE, and systemic treatment of Sjögren syndrome. Readers will find this first volume of Connective Tissue Disease to be an excellent source of information on the current understanding of, and clinical approach to, SLE and Sjögren syndrome that clearly conveys the progress made in recent years.

Part I  Systemic Lupus Erythematosus
1  Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   3
Dario Roccatello
 2  Epidemiology  of Systemic  Lupus  Erythematosus. . . . . . . . . . . . . . . . . . .   5 
Simone   Baldovino  and  Cristiana   Rollino 
 3  SLE  Pathogenesis:  From Apoptosis  to Lymphocyte  Activation. . . . . . .   23 
Danilo   Squatrito ,  Giacomo   Emmi ,  Elena   Silvestri , 
Domenico   Prisco ,  and  Lorenzo   Emmi 
 4  Systemic  Lupus  Erythematosus:  Clinical  Aspects. . . . . . . . . . . . . . . . . . .   35 
Savino  Sciascia  and  Maria  Josè   Cuadrado 
 5  Autoantibodies  and Biomarkers:  Diagnostic  Aspects. . . . . . . . . . . . . . .   47 
Savino  Sciascia  and  Maria  Laura   Bertolaccini 
 6  Joint  Involvement  in Systemic  Lupus  Erythematosus. . . . . . . . . . . . . . .   61 
D a n i e l a  R o s s i ,  V i t t o r i o  M o d e n a ,  G .  B i a n c h i , 
R a ff aele  Pellerito ,  and  Dario  Roccatello 
 7  The  Spectrum  of Cutaneous  Manifestations  in Systemic  Lupus 
Erythematosus and Novel Classification. . . . . . . . . . . . . . . . . . . . . . . . . . .   77 
Simone   Ribero ,  Dan   Lipsker ,  and  Luca   Borradori 
 8  Lupus  Nephritis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   95 
A n t o n e l l o   P a n i ,  A n d r e a  A n g i o i ,  a n d  F r a n c o  F e r r a r i o 
 9  Neuropsychiatric  Systemic  Lupus  Erythematosus. . . . . . . . . . . . . . . . .   113 
Karen   Schreiber  and  Soren   Jacobsen 
10  Cardiovascular  Issues  in SLE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   133 
M a r i a  G e r o s a ,  Mara Taraborelli, 
Pier Luigi Meroni,  a n d  A n g e l a  T i n c a n i 
11  Systemic  Lupus  Erythematosus  and Pregnancy. . . . . . . . . . . . . . . . . . . .   147 
12  Vitamin  D,  Autoimmune  Diseases,  and Systemic 
Lupus Erythematosus. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   159 
Sabrina   Paolino ,  Vanessa   Smith ,  Carmen   Pizzorni , 
Bruno   Seriolo ,  Alberto   Sulli ,  and  Maurizio   Cutolo 
13  The  Impact  of aPL  Detection  on Pregnancy. . . . . . . . . . . . . . . . . . . . . . .   169 
Maria  Tiziana   Bertero ,  Anna   Kuzenko ,  and  Mario   Bazzan 
14  Systemic  Lupus  Erythematosus  and Antiphospholipid  Syndrome. . .   183 
Jose  A.   Gómez-Puerta  and  Ricard   Cervera 
15  Disease  Activity  Indices  and Prognosis 
of Systemic Lupus Erythematosus. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   199 
Luca   Iaccarino ,  Maddalena   Larosa ,  and  Andrea   Doria 
16  Conventional  Treatment  of Systemic  Lupus  Erythematosus. . . . . . . .   213 
Giacomo   Quattrocchio ,  Fernando   Fervenza , 
and  Dario   Roccatello 
17  Innovative  Therapies  in Systemic  Lupus  Erythematosus. . . . . . . . . . .   239 
Roberta   Fenoglio ,  Fernando   Fervenza ,  and  Dario   Roccatello 
18  SLE  in  21st  Century. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   263 
Graham Hughes
Part  II  Sjögren  Syndrome
19  Classification  Criteria  of Sjögren’s  Syndrome. . . . . . . . . . . . . . . . . . . . .   267 
Chiara   Baldini  and  Stefano   Bombardieri 
20  Etiopathogenesis  of Sjogren’s  Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . .   279 
Adrianos   Nezos  and  Clio  P.   Mavragani 
21  Autoantibodies  in Sjögren’s  Syndrome  and Laboratory  Markers. . . .   293 
Efstathia  K.   Kapsogeorgou  and  Athanasios  G.   Tzioufas 
22  Parotid  and Submandibular Involvement in Sjögren’s Syndrome. . . .   309 
Savino   Sciascia ,  Andrea   De  Marchi ,  and  Dario   Roccatello 
23  Extraglandular  Involvement  in Sjögren’s  Syndrome. . . . . . . . . . . . . . .   319 
Roberta   Priori ,  Antonina   Minniti , 
Giovanna   Picarelli ,  and  Guido   Valesini 
24  Dry  Eye  in Sjögren  Syndrome:  Diagnostic  Tools  and Therapy. . . . . .   333 
Rita   Mencucci ,  E.   Favuzza ,  and  L.   Terracciano 
25  Neurological  Involvement  in Sjögren’s  Syndrome. . . . . . . . . . . . . . . . .   349 
Roberto   Cavallo ,  Maria  Roberta   Bongioanni ,  and  Paola   Richiardi 
Contents
vii
26  Lymphoproliferative  Disorders  Associated 
with Sjögren Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   357 
Corrado   Tarella ,  Safaa   Ramadan ,  Angela   Gueli , 
Simona   Sammassimo ,  and  Stefano   Pileri 
27  Pathogenetic  Aspects  of Sjögren’s  Syndrome:  Relationships 
with Cryoglobulinemia and Lymphoproliferation of MALT. . . . . . . .   371 
Salvatore   De  Vita  and  Luca   Quartuccio 
28  Systemic  Therapy  of Sjögren  Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . .   383 
Soledad   Retamozo ,  Pilar   Brito-Zerón ,  Hoda   Gheitasi , 
Verónica   Saurit ,  and  Manuel   Ramos-Casals 
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   399

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