Download Bone Disease of Organ Transplantation PDF

Download Bone Disease of Organ Transplantation PDF
by Juliet Compston (Editor), Elizabeth Shane (Series Editor

Bone disease, particularly osteoporosis, has emerged as a common and serious complication of solid organ transplantation. In recent years there have been real advances in our understanding of the pathogenesis and pathophysiology of bone loss, however treatment studies have been relatively sparse and successful strategies to reduce skeletal morbidity after transplantation remain to be clearly established. This book provides a unique resource for the many health professionals involved with transplantation of bone disease, both in terms of its scientific background and the management of the disease in clinical practice.

Bone Disease of Organ Transplantation offers for the first time a comprehensive review of scientific and clinical aspects of bone disease in transplant recipients. The role of glucocorticoids and other immunosuppressive drugs is discussed in detail and there is a chapter devoted to the neglected but important area of interactions between bone and the immune system. Bone biology and mineral metabolism are reviewed and our current state of knowledge about the pathogenesis and pathophysiology of this bone disease is covered in some detail. Different types of transplantation are discussed separately, since both pre-existing and postoperative bone disease may differ according to the organ transplanted. Not only are the more common transplants covered (kidney, liver, heart, and lung), but the reader will also find reviews of bone disease occurring after kidney–pancreas and pancreas transplantation and bone marrow transplantation. There is also a chapter on the effects of transplantation during childhood and adolescence, a topic that has previously received little coverage. Finally, the management of transplantation bone disease is discussed in detail, with respect both to optimization of skeletal health prior to and prevention and treatment of bone loss after transplantation

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