Download Arthritis: Pathophysiology, Prevention, and Therapeutics PDF

Download Arthritis: Pathophysiology, Prevention, and Therapeutics PDF
by Debasis Bagchi (Editor), Hiroyoshi Moriyama (Editor), Siba P. Raychaudhuri (Editor

A debilitating disease of pain, inflammation, and loss of mobility and quality of life, arthritis takes victims of all ages, from young children to seniors. Usually chronic, the broad term arthritis refers to nearly 100 distinct manifestations, each with their own etiology, pathophysiology, and treatment. With medical research getting so much attention, it is no wonder there have been recent leaps in the investigation into arthritis treatment. It is important to have a high quality, trusted compendium to capture the breadth and depth of new information in the field.

Covering cutting-edge information on arthritic diseases and their treatment, Arthritis: Pathophysiology, Prevention, and Therapeutics details the intricacies of arthritis and inflammatory responses, their consequences, their economic burden, and their impact on society. Offering a mechanistic approach to pathophysiology and treatment, the book begins with an overview of rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

Section Two highlights the consequences of arthritis and the link between arthritis and obesity, diabetes, and cardiovascular disease, as well as other related disabilities. The third section focuses on antiarthritic drugs, including an overview and update on antiarthritic drug development by Dr. Micheal G. Lyon from Stanford University School of Medicine, and a chapter on nonsteroidal anti-inflammatory drugs. Other chapters cover biologics in arthritis treatment, topical applications, and the use of hyaluronan and hyaluronic acid in osteoarthritis and rheumatoid arthritis.

Sections Four and Five are devoted to natural therapeutic and orthopedic interventions such as glucosamine and chondroitin, MSM, capsaicin, shark cartilage, and fish oil, while Section Six discusses nonpharmacological approaches including physical exercise and acupuncture. The final section provides a commentary on the correlation between arthritis and the aging society and how exercise, nutrition, and preventative strategies can help the world and mankind in promoting human health.

Osteoarthritis (OA), also known as degenerative joint disease or osteoarthrosis, is the most common type of arthritis. OA is a functional disorder of the joint, characterized by a change in joint shape secondary to a loss of articular cartilage, osteophyte formation, subchondral sclerosis, bone marrow lesions, and synovial proliferation, with consequent alteration of mechanical properties that result in decreased stability, movement, and loading [1, 2]. It is estimated to affect more than 27 million people in the United States and is the leading cause of physical disability and impaired quality of life in the industrialized countries. OA is strongly related to but not caused by aging, with most affected persons being older than 50 years. The higher life expectancy, the aging population, and the increase in number of overweight persons in the United States have led to an increase in prevalence of OA 

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