DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology PDF

DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology PDF
by Fumio Hanaoka (Editor), Kaoru Sugasawa (Editor)

Replication, recombination, and repair of DNA are fundamental molecular mechanisms for organisms to maintain (and sometimes intentionally alter) genetic information. Although these processes, individually, have been important subjects of molecular biology since its emergence, we have recently become aware that they are actually much more intimately related to one another than we used to realize.
Furthermore, the research fields of DNA replication, recombination, and repair have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other pivotal processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation of gene expression, and so on. Most importantly, now we know that
DNA replication, recombination, repair, and related functions form a sophisticated network in order to maintain, regulate, and even evolve genetic information. Since quite some time ago, perturbation of normal DNA replication, recombination, or the
repair process has been implicated in carcinogenesis, mainly through inducing genome instability. However, recent studies have revealed that malfunctioning of the above network system, as a whole, may be implicated in a much wider variety ofpathological states of higher organisms (e.g., ageing, and neurological and developmental abnormalities). This book is intended to comprehensively overview the detailed molecular mechanisms of and functional crosstalk among DNA replication, recombination, repair, and related processes, with the special consciousness of their biological as well as clinical consequences. It comprises 7 parts and 21 chapters, contributed by more than 50 outstanding scientists from the related research fields. The first 3 parts, each containing 3 chapters, are dedicated to describing basic molecular mechanisms and regulation of DNA replication, recombination, and repair, respectively. Part IV is concerned with the biological processes involved in generation and/or prevention of genome instability and mutagenesis, particularly during DNA replication or after DNA double-strand breaks. In part V, there is discussion of how characteristic structural elements of eukaryotic chromosomes, centromeres, and telomeres are organized and contribute to maintenance of genome stability. Part VI describes the molecular mechanisms underlying checkpoint controls of the cell cycle as well as regulation of cellular senescence and apoptosis, all of which play crucial roles in prevention of carcinogenesis. The final part is concerned with histone modifications and DNA methylation, which are involved in epigenetic controls of transcription and other DNA metabolisms and are regulated by DNA replication and/or repair machineries.
This book is expected to be used by a wide audience: graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only those directly related to DNA replication, recombination, and repair, but also those from related fields (chromosomes, cell cycles, transcription, epigenetics, and similar processes). Considering the diversity of physiological functions as well as diseases related to the genome regulatory networks, individuals in cancer biology, neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields may be interested as well. We are especially thankful to all the authors for their great contributions, devoting their valuable time to preparation of the manuscripts. We are also indebted to the editorial staff members of Springer for their kind support in making this book publishable. We hope that the book will help many researchers to acquire and understand the current knowledge in these fields, which are expected to grow into innovative areas in the near future

DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology PDF

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