Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer PDF

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We are honored and privileged to have been part of assembling and editing Antibody–Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer. This is a critical field of drug discovery, development, and commercialization focused on improving a patient’s quality of life by specifically targeting the disease with a highly effective therapy, while simultaneously sparing normal tissue. We worked closely with distinguished, knowledgeable, and well‐known industry, academic, and government researchers, drug developers, and clinicians to present a comprehensive story with concrete examples of novel therapies across various indications in oncology. We  intentionally have overlap in various chapters to ensure full coverage of essential topics, which allows for a variety of opinions and strategies to be thoroughly explored. As the reader may be aware, in order to effectively treat cancer and improve the quality of life for patients, therapeutic oncology molecules must kill all cancer cells without adversely affecting normal cells. Combinations of cytotoxic chemotherapeutic drugs have been the traditional means to this end, but often have off‐target dose‐limiting toxicities in normal cells and tissues that prevent sufficient exposure to kill all tumor cells. While the advent of engineered targeted monoclonal antibodies (mAbs) significantly improved the clinical outcomes for patients with several types of cancer, optimal efficacy requires they be given in combination with cytotoxic chemotherapy. Antibody–drug conjugates (ADCs) have the advantage of specifically targeting cancer cells to deliver cytotoxic drugs. This combination has created widespread enthusiasm in the oncology drug development community as well as in patient advocacy networks and can be largely explained by the properties of these molecules in their exquisite binding specificity and their substantially decreased toxicity profile. Several approaches are being evaluated including linkage of mAbs to highly cytotoxic drugs and targeted delivery of cytotoxic drug payloads in liposomes. This book will provide academic oncologists, drug researchers, and clinical developers and practitioners with a depth of knowledge regarding the following topics: (i) ADC fundamentals, (ii) molecules, structures, and compounds Preface xxii Preface included in this class, (iii) chemistry manufacturing and controls associated with ADC development, (iv) nonclinical approaches in developing various ADCs, (v) clinical outcomes and successful regulatory approval strategies associated with the use of ADCs, and (vi) case studies/examples (included throughout) from oncology drug discovery. Readers will be educated about ADCs so that they can affect important improvements in this novel developing field. They will have practical, proven solutions that they can apply to improve their ADC drug discovery success. We feel this book will be a valuable reference to significantly augment the scope of currently available published information on ADCs. Considering how expansive this field is and the potential benefit to researchers, clinicians, and ultimately our patients, we felt a more comprehensive book covering the newest cutting‐edge information was essential to the field of oncology drug development

Antibody-Drug Conjugates Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer PDF

 

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